Why You Are Still Insulin Resistant on a Low-Carb Diet

Are you doing all the right things but still getting all the wrong results? If your low-carb, high-protein, or ketogenic diet isn’t fixing your insulin resistance and you haven’t been achieving your weight loss goals, the polyol pathway might be the culprit.

In this solo episode, Betty talks all about the polyol pathway—a process in the body that helps break down sugars. She explains what happens biologically when we eat too much sugar and have an excess of glucose and how triggering the polyol pathway can negatively impact our health.

After walking you through the various ways the polyol pathway can be triggered, Betty will give you a handful of easy ways to regulate the polyol pathway and avoid activating it.

This episode might be the secret ingredient you need to finally hit your health goals.

Key Topics/Takeaways:

• What the polyol pathway is and how it works.
• Impacts of too much glucose in the body.
• How the polyol pathway is related to dehydration and salt intake.
• The role of estrogen in regulating the polyol pathway.
• Oxidative stress.
• The interaction between fructose and the fat switch.
• The mitochondrial function at the cell.
• What triggers the polyol pathway.

Memorable Quotes:

“When there’s too much sorbitol and fructose being produced and not enough being used, it’s gonna cause a problem.” (2:48, Betty)

“It’s really important to be mindful of hydration. You have got to make sure that you’re hydrated appropriately, particularly before eating.” (5:47, Betty)

“The interesting thing is fructose doesn’t create satiety. So satiety is that sensation in which you feel like you’ve eaten and you’ve gotten calories and you’re satisfied. Fructose does not do that, and particularly high fructose corn syrup, which leads to more eating, more desire for sugar, just more food.” (12:44, Betty)

“Part of the process is to correct this polyol pathway mechanism to make sure that the cells can do what they need to do so we can become more metabolically flexible, so our body can actually burn that fat appropriately, even before we are in menopause.” (23:26, Betty)

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